Presently, only few high-end cryo-EM instruments are available in biosafety level 3 labs. Furthering the scope of structural virology ![]() Pathogenic virus research: unanswered questionsĬryo-electron microscopy (cryo-EM) has been used to study viral pathogens for more than 20 years, resolving the structures of viruses such as Zika, Ebola, HIV, and coronaviruses.ĭuring the COVID-19 pandemic, cryo-EM played a pivotal role in accelerating vaccine development and antiviral drug discovery for this newly emerging pathogen.ĭespite the achievements of virus research, many viral pathogens have yet to be studied, and questions about their behavior remain unanswered. Structural virology provides critical insights into virus morphology, life cycle, and interactions with host cells, enabling researchers to address these fundamental questions.
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